By Agence France-Presse
The Amtrak train traveling between New York and Miami collided with the CSX freight train and derailed in Cayce, near Columbia, the state's capital, at around 2:30 am on Sunday.
Amtrak said in a statement that the lead engine derailed along with some passenger cars. Eight crew members were on board.
The Lexington County Sheriff's Department confirmed all passengers had been evacuated from the train. Officials added that although 5,000 gallons of fuel spilled following the crash, there was no danger to the public.
Meanwhile, the Red Cross said it was providing support to victims.
The accident comes days after another Amtrak train carrying several dozen Republican lawmakers including US House Speaker Paul Ryan collided with a garbage truck in Virginia, killing one person and sending six others, including a congressman, to hospital.
In December, three people were killed when an Amtrak passenger train derailed in Washington state near the city of Tacoma, sending cars flying off a bridge and onto a busy interstate road.