By Agence France-Presse
Meng has resigned "with immediate effect" and Senior Vice President Kim Jong Yang of South Korea has become acting president, Interpol said in a statement.
Meng, the first Chinese president of Interpol, was last heard from on September 25 as he left Lyon, where the police agency is based, for China.
That day, his wife said he sent a social media message telling her to "wait for my call", before sending a knife emoji signifying danger. She said she feared for his life.
Beijing, which had remained tight-lipped about Meng's fate since French officials disclosed his disappearance on Friday, said in a one-line statement that Meng "is currently under investigation on suspicion of violating the law".
Interpol also said in its statement that it will elect a new president for the remaining two years of the current mandate at its general assembly to be held in Dubai on November 18-21.