By Agence France-Presse
The bloodletting is the latest to hit global equities, which have been pummelled this year by a wave of problems led by the China-US trade war and rising Federal Reserve interest rates.
On top of those in recent weeks has been a brewing nuclear standoff between the US and Russia, the killing of a Saudi journalist, Brexit and Italy's budget row with the European Union.
US stocks have broadly managed to avoid the hefty selling witnessed elsewhere -- even clocking up a few record highs -- thanks to a strong economy and mostly positive corporate results.
However, New York has finally succumbed as investors contemplate an end to the decade of cheap credit and the imposition of steep tariffs by the US and China in their ever-deepening trade row, to which there is no end in sight.
Wednesday say the Dow and the S&P 500 wipe out their gains for the year, while the Nasdaq dived more than four percent as the under-pressure tech sector took another beating.
The selling came after data showed US home sales were at their slowest pace for nearly two years, while the Fed said firms nationwide are worried about the tariffs as well as labour shortages.
And those losses filtered through to Asia, where Tokyo was scythed 2.2 percent, Shanghai dived almost three percent and Sydney sank 2.1 percent, also losing its gains for the year.
'Sharks are circling'
Hong Kong lost more than two percent, with airline Cathay Pacific collapsing 6.5 percent after after it admitted to suffering a major data leak affecting up to 9.4 million passengers.
Seoul shed 2.8 percent as data showed the South Korean economy expanded at a slower pace than expected in the third quarter.
Wellington lost 1.2 percent, Manila fell 2.4 percent and Taipei retreated 2.5 percent.
"With the S&P and Nasdaq having been drawn into the global equity maelstrom, the US bellwethers are no longer the invincible titans that have held up global market sentiment for what seems like an eternity," said Stephen Innes, head of Asia-Pacific trade at OANDA.
"With China-US trade hopes fading as both sides appear to be digging in for the long haul things could get blustery in a hurry. Indeed the sharks are circling."
Key figures around 0210 GMT
Tokyo - Nikkei 225: DOWN 2.2 percent at 21,377.20 (close)
Hong Kong - Hang Seng: DOWN 2.3 percent at 24,666.92
Shanghai - Composite: DOWN 1.9 percent at 2,554.36
Euro/dollar: UP at $1.1408 from $1.1393 at 2100 GMT
Pound/dollar: UP at $1.2892 from $1.2884
Dollar/yen: DOWN at 111.90 from 112.19 yen
Oil - West Texas Intermediate: DOWN 57 cents at $66.25 per barrel
Oil - Brent Crude: DOWN 68 cents at $75.49 per barrel
New York - Dow: DOWN 2.4 percent at 24,583.42 (close)
New York - S&P 500: DOWN 3.1 percent at 2,656.10 (close)
New York - Nasdaq: DOWN 4.4 percent at 7,108.40 (close)
London - FTSE 100: UP 0.1 percent at 6,962.98 points (close)ใ