Vinci said after beating the top-ranked player two from three sets that she just tried to forget that Williams was on the court. "I tried to keep the ball on the court and I won!"
Williams is 4-0 lifetime against Vinci.
Williams, on a 33-match Grand Slam win streak and a 26-match US Open win streak, was only two victories shy of completing two of the most incredible achievements in the history of tennis, playing her best tennis at an age once thought impossible for such success.
The 33-year-old American, who already holds all four major titles, is chasing the first calendar Grand Slam since Steffi Graf in 1988 and trying to match Graf's Open Era career record of 22 Slam singles titles, two shy of Margaret Court's all-time record.