The accident happened in the early morning of March 6, when the man fell through the window of his hotel room.
The police said the businessman checked into the hotel on February 28 to do business with Sojitz Corp Yangon, a food processing company.
Police said they are investigating the case.
The name of the Japanese was not available.
A Korean man living on the tenth floor of Ocean Centre in Mayangone Township committed a suicide by jumping from his room on March 2, according to police records.