Pol Captain Prachak Khamnak from Mueang Buri Ram police station said the accident had occurred at the curve of a main road in Ban Sai Yong in Tambon Krasang at 4.30am.
Two passengers, one from each of the vehicles, died at the scene, while both drivers were rushed to Buri Ram Hospital after suffering severe injuries.
The car driver was identified as Pol Senior Sgt-Major Niranwa Thanapatruangphaisarn, and the pickup driver as Prawit Bamrungchue.
Prawit’s passenger was named as Somparn Bamrung, and Niranwa’s as Thiparat Srichanyaem.
Police said the two vehicles had collided at the curve apparently at high speed.