
The Boeing 777-200 aircraft vanished about an hour after departing Kuala Lumpur at 12:41 am (1641 GMT Friday). It had been due to land in Beijing at 6:30 am.
The airline said it was carrying a total of 227 passengers, including 2 infants, and 12 crew members.
Search and rescue teams from Malaysia, Vietnam, China, Singapore and the Philippines have been dispatched to the South China Sea, the area flight MH370 should have been travelling over at the time contact was lost.
No wreckage of the aircraft has yet been spotted.
DPA