Michele Leonhart, 59, head of the anti-drug trafficking law enforcement agency, is retiring in mid-May, Attorney General Eric Holder said in a statement.
The DEA came under intense criticism following a Justice Department report at the end of March that found agents attended orgies with prostitutes they should have known were hired by a drug cartel.
The sex parties reportedly took place in Colombia.
Agents attended the parties hosted at government-leased headquarters over the course of several years, the report said.