A police patrol unit spotted a Toyota Fortuner SUV at the bank of the river in Ban Huay Suak in Tambon Buhom at 10pm.
When the driver saw police he attempted to speed away but a policeman fired at the tyres bringing the vehicle to a halt.
Police saw men leave the vehicle and flee.
Police found 6.4 million meth pills and 160 kilograms of crystal meth in the vehicle.