Traditional vaccines boost the immune system's response to infections.
The new project will inject people with genetic material, such as DNA or RNA, in hopes of spurring a person's own cells to make specific antibodies capable of fighting Ebola or other pathogens.
"The person's body is the factory," said Dr. James Crowe of Vanderbilt University, one of the collaborators on the project. "It's a cool idea."
Experts say the method, if proven to be safe and effective, would be faster and cheaper than conventional drug production and could potentially be used to treat illnesses such as seasonal flu or malaria.
Antibodies are typically grown in large vats of mammal cells or in some cases, tobacco plants, such as Mapp Biopharmaceutical's experimental Ebola treatment ZMapp.
The Defense Advanced Research Projects Agency (DARPA), the Pentagon's elite research arm, has awarded Emory up to $10.8million over three years to direct the project.