Pol Lt Col Somsak Ketpibul, deputy commander of Thawat Buri police said the accident happened on the district bypass road in front of the Piyabodin housing estate.
Somsak said the senior officer's black BMW hit two motorcycles that were driving against traffic and each motorcycle had two pillion riders.
He said a 14-year-old girl and two 14-year-old boys died at the Roi Et Hospital while three other teenagers were severely injured.
He said the driver of the BMW fled the scene.
Somsak said the BMW car belongs to a senior police officer in Roi Et. He declined to identify the officer pending a summons for questioning and formal charges.