Pol Lt Col Patiwat Yodkwan, an inspector from Patong police station, said the fire broke out at the SB Plaza near the Jungceylon Shopping Centre on Rat-uthit road in Tambon Patong at 2 am.
Fire fighters took about an hour to control the blaze, which damaged 12 rows of shops.
No one was injured in the fire.
Police have yet to investigate the cause.