Police said the accident happened at 7.50am on the Chiang Mai-Fang Road in Ban Mieang Pha village in Tambon Rimnua, Mae Rim district.
Police said the truck was apparently speeding when it lost control on the slippery road following rains and crashed into the fence of the house belonging Siwaporn Kojirawathee, 58.
Siwaporn said she heard a loud noise and came out to see the truck crashed into the fence.
The truck driver, Surasak Chanthasit, 43, died behind the wheel, while Thitiporn Saramool 35, was killed beside him. Another employee, Witthaya Chartsanga, 28, was injured.